Mouse Models

Common mouse models of tauopathy reflect early but not late human disease

Mouse models that overexpress human mutant Tau (P301S and P301L) are commonly used in preclinical studies of Alzheimer’s Disease (AD) and while several drugs showed therapeutic efects in these mice, they were inefective in humans. This leads to the question to which extent the murine models refect human Tau pathology on the molecular level. AD mouse models that overexpress human Tau using risk mutations are a suitable tool for testing drug candidates that aim to intervene in the early formation of insoluble Tau species promoted by increased phosphorylation of Tau.