Hyman Lab Hyman Lab

Transcriptomics and Neurodegeneration

Transcriptomics and Neurodegeneration

Project Overview

In the last several years we have been able to leverage new, stronger omics technologies to help analyze longitudinal changes in human brain physiology, utilizing human brain material from patients who had donated tissue for research. These studies reveal unexpected connections of toxicity and cell death pathways, opening new avenues towards prevention of neurodegeneration.

Publications

  • Das, S. et al. (2023). “Distinct transcriptomic responses to Aβ plaques, neurofibrillary tangles, and APOE in Alzheimer’s disease.” Alzheimer’s & Dementia 20(1), 74-90.
  • Wachter, A. et al. (2024). “Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer’s disease reveals distinct sequential responses to Aβ and tau.” Acta Neuropathologica 147(1), 65.
  • Collins, M. et al. (2025). “Ubiquitin-Proteasome System Dysregulation in Alzheimer’s Disease Impacts Protein Abundance.” [Preprint]
Research Areas
Aging Alzheimer's Disease Amyloid-Beta Amyloid-Beta Plaques APOE APOE2 APOE4 Astrocytes Blood-Brain Barrier Brain Heterogeneity Burst Firing Cell Death Pathways Cryptic Splicing Endothelial Cells Gene Therapy Glial Transcriptome Hippocampal Neurons Mouse Models Myeloid Cells Neurodegeneration Neurofibrillary Tangles Neuronal Genomics Post-Translational Modifications Protein Abundance Somatic Mutations Tau Tau Pathology Tauopathy TDP-43 Transcriptomics Ubiquitin-Proteasome System
Tags
Gene Regulation Grant NIH